NCG 4.0 reports information on:
of a manually curated list of 2,000 protein-coding cancer genes and 64 OncomiRs.
Cancer genes are genes with a driver role in the onset of human cancer upon mutations of their sequence and/or amplifications of their genomic locus.
537 are known cancer genes from the Cancer Gene Census and from a list of genes that undergo cancer-specific amplifications. Their involvement in cancer is documented in the literature.
1463 are candidate cancer genes that derive from the manual curation of 77 whole genome or whole exome cancer-resequencing screenings. Their involvement in cancer is inferred with various statistical methods.
Cancer genes in NCG 4.0 are mutated in 23 cancer types: